Fig. 6: PV and SST plasticity differentially regulates Schaffer collateral and temporoammonic excitation of CA1 pyramidal neurons.

a Diagram of a simulated, rate-based CA1 pyramidal cell before and after the induction of inhibitory plasticity (iPlas). A single two-compartment neuron receives inputs from four sources: distally targeting temporoammonic, proximally targeting Schaffer collaterals, distally targeting inhibition from SST interneurons, and proximally targeting inhibition from PV interneurons. iPlas leads to PV-iLTD and SST-iLTP. b Correlation between Schaffer collateral activity and CA1 somatic activity (left) and temporoammonic activity and CA1 somatic activity (right) before and after iPlas at PV and SST synapses (PV-iLTD and SST-iLTP). c–f CA1 somatic activity before and after iPlas (either PV-iLTD or SST-iLTP) under the individual stimulation of either Schaffer collaterals or temporoammonic inputs. c Schaffer collateral-driven CA1 somatic activity is enhanced upon PV-iLTD (p < 0.0001, paired t-test, two tailed, n = 10). d CA1 somatic activity driven by temporoammonic input after PV-iLTD is unchanged (p = 0.391, paired t-test, two tailed, n = 10). e CA1 somatic activity driven via Schaffer collateral input after SST-iLTD is unchanged (p = 0.572, paired t-test, two tailed, n = 10). f SST-iLTP leads to a reduction in CA1 somatic activity in response to temporoammonic input (p < 0.0001, paired t-test, two tailed, n = 10). Data presented as mean values ± SEM. See also Supplementary Fig. 5.