Fig. 7: CA1 output driven by Schaffer collateral or temporoammonic inputs is differentially regulated by PV-iLTD and SST-iLTP. | Nature Communications

Fig. 7: CA1 output driven by Schaffer collateral or temporoammonic inputs is differentially regulated by PV-iLTD and SST-iLTP.

From: Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output

Fig. 7

a Diagram showing the experimental design where electrically stimulated Schaffer collaterals evoke action potentials in CA1 pyramidal neurons with example current-clamp traces before and after induction of PV-iLTD (0 ms pre and post pairing) (top). Spike probability timecourse (left) and average spike probability during baseline (BL) and 20–25 min after induction of PV-iLTD (Plas) (right) (p = 0.0288, paired t-test, two tailed, n = 6 cells). b Same as (a) but for the stimulation of the temporoammonic pathway (p = 0.5264, paired t-test, two tailed, n = 6 cells). c Diagram showing electrical stimulation of Schaffer collaterals with example traces before and after induction of SST-iLTP (0 ms pre and post pairing) (top). Spike probability timecourse (left) and average spike probability during baseline (BL) and after SST-iLTP (Plas) (right) (p = 0.667, paired t-test, two tailed, n = 8 cells). d Same as (c) but for stimulation of the temporoammonic pathway (p = 0.0203, paired t-test, two tailed, n = 6 cells). Data presented as mean values ± SEM. Scale bars: 100 ms, 20 mV. See also Supplementary Fig. 6.

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