Fig. 5: Viological and histopathological analysis of macaque airway tissues. | Nature Communications

Fig. 5: Viological and histopathological analysis of macaque airway tissues.

From: An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques

Fig. 5

a The viral loads in the nine anatomic locations of macaque airway. The tissues of trachea, left and right bronchus, and the upper, middle, and lower locations of the left and right lung were collected at euthanasia. The viral genomes in the tissue homogenates were assessed by qRT-PCR. All the data points represent the mean values of two technical replicates. The dot line indicates the limit of detection (1000 copies per g tissue). b–f Histopathological changes in the lungs of SARS-CoC-2 challenged non-vaccinated macaques (b) and vaccinated macaques (d–f), and an unchallenged macaque IM vaccinated with 1 × 1010 vp Ad5-S-nb2 (c). The lung tissue sections were stained with hematoxylin and eosin (H&E). One representative graph from each macaque is shown. Scale bars are 50 μm and indicated in each panel. Source data are provided as a Source Data file.

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