Fig. 5: Heroin leads to FYN-mediated hyperphosphorylation of Tau protein. | Nature Communications

Fig. 5: Heroin leads to FYN-mediated hyperphosphorylation of Tau protein.

From: Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder

Fig. 5

a Immunocytochemistry analysis of vehicle and morphine-treated primary cortical-striatal co-cultured neurons revealed increased phosphorylation of Tyrosine-18 of Tau in morphine-treated cells (n = 3 biological replicates/group, Student’s t-test, t4 = 4.374, p = 0.0119). ×40 magnification, scale bars represent 33 µm. b, c Western blots from the caudate-putamen of heroin self-administering rats showed Tau hyperphosphorylation in vivo both 1 h (B; n = 5/group, Student’s t-test, t8 = 2.359, p = 0.0461) and 24 h (c; n = 6/group, Student’s t-test, t10 = 2.503, p = 0.0313) following the last self-administration session. Data are represented as mean ± SEM. DAPI 4,6-diamidino-2-phenylindole. Source data are provided as a Source Data file.

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