Fig. 7: Computational modeling of energetics.
From: Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy
a Schematic image of key parameters used in a three compartment model of CaMKII, creatine kinase (CK), and mitochondrial energetics. b Computer stimulation results were compared in WT, CKmito, mtCaMKII, and mtCaMKII x CKmito interbred conditions. The ratios of PCr/ATP and ATP/ADP were calculated at the end of 5 min cardiac cycle (simulated using pulsatile functions to oscillate ATP hydrolysis and cytosolic calcium).
