Fig. 2: Dynamic and functional analysis of the (phospho)proteome data.
From: Dynamic remodelling of the human host cell proteome and phosphoproteome upon enterovirus infection
a Heat map of z-scored protein abundances (LFQ intensities) of the proteins differentially expressed through time (ANOVA, FDR < 0.05). The two clusters encompass 587 downregulated proteins (cluster A) and 211 upregulated proteins (cluster B). b Heat map and hierarchical clustering of the z-scored site intensity of 14,371 CVB3-regulated phosphosites (ANOVA, FDR < 0.05). The three clusters discriminate between upregulated (cluster 1), dynamically regulated (cluster 2) and downregulated (cluster 3) phosphosites. c Upstream kinase prediction analysis via NetworKIN of the CVB3-regulated phosphosites suggests that several classes of kinases are activated differently during the progression of the infection. Kinases are grouped based on their families. Source data are provided as a Source Data file for all panels.
