Fig. 7: CRISPR dCAS9 activation (CRISPRa) targeting of an RA-associated variant. | Nature Communications

Fig. 7: CRISPR dCAS9 activation (CRISPRa) targeting of an RA-associated variant.

From: Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis

Fig. 7

The region around an associated RA variant (rs9603616) on chromosome 13 intronic of the COG6 gene was targeted in the HEK2937T cell line, using p300 as the activator. a Fold change (qPCR) effect on FOXO1 gene expression compared to negative control. b Fold change (qPCR) effect on COG6 gene expression compared to negative control.

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