Fig. 3: Manhattan plot displaying bidirectional variant-specific pleiotropy from ASSET.
From: Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts
The red dashed line represents the genome-wide significance threshold (P < 5 × 10−8), and the black dotted line represents a suggestive threshold (P < 1 × 10−6). Highlighted are loci with overall pleiotropic P < 5 × 10−8, the two directional P < 0.05, and not in LD with a one-directional SNP with smaller P. Loci in purple are genome-wide significant loci where the overall pleiotropic P is less than all individual P for the selected cancers, and loci in green are genome-wide significant loci where the overall pleiotropic P is greater than at least one of the individual P for the selected cancers.
