Fig. 2: Blocking of viral attachment receptor CD55 and uncoating receptor FcRn by 6C5 and 4B10. | Nature Communications

Fig. 2: Blocking of viral attachment receptor CD55 and uncoating receptor FcRn by 6C5 and 4B10.

From: Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B

Fig. 2

a BIAcore SPR kinetics of FcRn or CD55 binding to E30. The RU curves are fitted globally to calculate the KD value for FcRn and CD55. b, c Competitive binding between 6C5 or 4B10 and CD55 (left) or FcRn (right). In the upper two diagrams of each panel, 6C5/4B10 was injected first, followed by either CD55, or FcRn, or ICAM5, the uncoating receptor for EVD68; in the lower two diagrams of the counterparts, CD55 or FcRn was injected first, followed by either 6C5, or 4B10, or 1A1. The related control groups were carried out as the other curves show. d Amount of virions remaining on the cell surface, as detected by real-time PCR, when exposed to 6C5 (left) or 4B10 (middle) or the mixture of 6C5 and 4B10 (right) before or after the virions attach to RD cells and the results here were expressed as mean ± SD.

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