Fig. 4: TPR is required for localization of TREX-2 complex at the NPC.
From: Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway
a–c Both TPR and GANP are required for PCID2 and ENY2 localization at the NE. Localization of mCherry-PCID2 and mCherry-ENY2 in cells after acute loss of TPR (a), NUP153 (b), or GANP (c). (see also Supplementary Fig. 7b, c). Note the changes in NPC localization of PCID2 and ENY2 (yellow arrowheads). Scale bar is 7 µm. All BSK-NUPs and NXF1 AID-tagged cell lines were treated with auxin for 2 h; GANP AID-tagged cell line was treated with auxin for 3 h. Data are representative of three independent experiments. d A schematic representation of the TREX-2–NPC interaction.
