Table 1 Genome-wide significant associations (pDiscovery < 1.09 × 10−9) of regional CTh.

From: Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Lobe

Region

Locus

Position

Lead SNP

Nearest gene

Annotation

N

pDiscovery

pReplication

ppooled

Temporal

Superior temporal

16q24.2

87225139

rs4843227

LOC101928708

Intergenic

21,887

2.79E−12

2.45E−05

2.31E−15

17q21.31

44861003

rs199504

WNT3

Intronic

21,887

1.30E−10

1.17E−04

5.85E−13

Middle temporal

14q23.1

59072144

rs10782438

KIAA0586

Intergenic

21,559

2.17E−13

2.76E−08

8.99E−21

Inferior temporal

2q35

217332057

rs284532

SMARCAL1

Intronic

21,885

1.03E−09

2.64E−01

3.04E−07

Banksts

14q23.1

59074878

rs160458

KIAA0586(

Intergenic

18,342

9.39E−10

2.42E−09

6.45E−18

Parietal

Superior parietal

16q24.2

87225101

rs9937293

LOC101928708

Intergenic

21,886

2.68E−14

1.64E−13

2.27E−27

1q41

215141570

rs10494988

KCNK2

Intergenic

21,886

2.60E−12

3.66E−08

2.63E−19

Postcentral

15q14

39633904

rs2033939

C15orf54

Intergenic

21,885

1.17E−73

5.18E−68

7.73E−136

Occipital

Lateral occipital

5q14.1

79933093

rs245100

DHFR

Intronic

21,886

2.68E−11

3.77E−06

1.16E−15

Cuneus

14q23.1

59624317

rs4901904

DAAM1

Intergenic

21,885

4.02E−14

3.17E−10

2.88E−23

Insula

16q12.1

51449978

rs7197215

SALL1

Intergenic

21,560

1.45E−13

2.00E−02

6.42E−12

9q31.3

113679617

rs72748157

LPAR1

Intronic

21,560

1.46E−10

1.38E−04

5.16E−13

  1. N number of individuals in meta-analysis, pDiscovery two-sided p-value of discovery GWAS meta-analysis in CHARGE, pReplication two-sided p-value of replication meta-analysis in ENIGMA, ppooled two-sided p-value of pooled discovery and replication meta-analysis, p-values are not adjusted for multiple comparisons, banksts banks of the superior temporal sulcus.
  2. in bold: significant replication—pReplication < 3.1 × 10−4 (= 0.05/Nl, Nl=160, total number of lead SNPs).
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