Table 2 Genome-wide significant associations (p_Discovery < 1.09 × 10⁻⁹) of global and regional CSA.

From: Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Lobe	Region	Locus	Position	Lead SNP	Nearest gene	Annotation	N	p_Discovery	p_Replication	p_pooled
	Global	17q21.31	44787313	rs538628	NSF	Intronic	18,617	1.78E−23	4.45E−22	1.00E−43
		6q22.32	126792095	rs11759026	MIR588	Intergenic	18,617	5.21E−22	1.45E−14	3.50E−34
		6q22.33	127204623	rs9375477	RSPO3	Intergenic	18,617	4.86E−13	1.60E−08	1.23E−19
		6q21	109000316	rs9398173	FOXO3	Intronic	18,617	6.84E−10	2.96E−03	2.05E−10
Frontal	Superior frontal	5q14.3	92187932	rs17669337	NR2F1-AS1	Intergenic	18,272	1.40E−11	2.05E−06	8.07E−16
	Caudal middle frontal	6q22.32	126876580	rs9388500	RSPO3	Intergenic	17,891	2.35E−11	NA	NA
	Pars opercularis	5q23.3	128734008	rs12187568	ADAMTS19	Intergenic	16,632	1.19E−16	NA	NA
	Pars triangularis	3q24	147106319	rs2279829	ZIC4	UTR3	18,265	6.32E−20	1.94E−27	1.20E−45
	Pars triangularis	7q21.3	96175094	rs10458281	LOC100506136	Intergenic	18,265	1.15E−17	2.42E−11	1.20E−26
	Precentral	15q14	39634222	rs1080066	C15orf54	Intergenic	18,267	8.45E−109	2.53E−95	1.00E−200
	Precentral	6q15	92002569	rs9345124	MAP3K7	Intergenic	18,267	5.50E−11	2.73E−14	9.91E−24
Temporal	Superior temporal	2p16.3	48274592	rs386645843	FBXO11	Intergenic	18,269	9.51E−12	8.42E−07	1.71E−16
		4q26	119249835	rs55699931	PRSS12	Intronic	18,269	2.08E−11	2.72E−02	6.96E−10
		2q23.2	150022681	rs13008194	LYPD6B	Intronic	18,269	5.94E−11	2.54E−07	1.92E−16
	Middle temporal	6q22.32	126964510	rs4273712	RSPO3	Intergenic	18,269	6.93E−10	1.07E−04	1.99E−12
	Banksts	14q23.1	59072226	rs186347	KIAA0586	Intergenic	18,265	4.11E−10	1.83E−09	4.93E−18
	Fusiform	17q21.31	44822662	rs199535	NSF	Intronic	18,269	1.01E−13	1.14E−06	8.13E−18
	Transverse temporal	2q23.2	150012936	rs2046268	LYPD6B	Intronic	18,264	9.09E−10	3.21E−10	1.78E−18
Parietal	Superior parietal	15q14	39632013	rs71471500	C15orf54	Intergenic	18,270	3.85E−24	5.55E−19	5.88E−41
	Superior parietal	19p13.2	13109763	rs68175985	NFIX	Intronic	17,324	8.84E−11	2.68E−17	2.90E−26
	Inferior parietal	20q13.2	52448936	rs6097618	SUMO1P1	Intergenic	18,267	1.78E−16	NA	NA
		12q14.3	65797096	rs2336713	MSRB3	Intronic	18,267	1.24E−12	2.99E−12	2.85E−23
		2p25.2	4563477	rs669952	LINC01249	Intergenic	18,267	4.47E−10	1.37E−08	4.73E−17
	Supramarginal	15q14	39633904	rs2033939	C15orf54	Intergenic	18,272	9.07E−27	1.61E−28	1.59E−53
		14q23.1	59627631	rs2164950	DAAM1	Intergenic	18,272	1.25E−13	3.79E−14	3.46E−26
		3q24	147106319	rs2279829	ZIC4	UTR3	18,272	7.38E−12	4.24E−16	2.29E−26
	Postcentral	15q14	39634222	rs1080066	C15orf54	Intergenic	18,265	5.65E−47	2.44E−36	1.87E−80
		3q24	147106319	rs2279829	ZIC4	UTR3	18,265	1.90E−21	1.69E−26	2.92E−46
		9q21.13	76144318	rs67286026	ANXA1	Intergenic	18,265	3.58E−12	8.04E−06	7.82E−16
	Precuneus	14q23.1	59628609	rs74826997	DAAM1	Intergenic	18,270	2.40E−24	4.41E−18	4.59E−40
		6q23.3	138866268	rs9376354	NHSL1	Intronic	18,270	7.80E−13	4.12E−08	7.28E−19
		3q26	190666643	rs1159211	SNAR-I	Intergenic	18,270	4.49E−10	2.04E−05	1.59E−13
Occipital	Lateral occipital	14q23.1	59627631	rs2164950	DAAM1	Intergenic	18,269	3.04E−26	2.92E−15	2.25E−38
	Lingual	14q23.1	59628679	rs76341705	DAAM1	Intergenic	18,270	1.57E−20	8.67E−13	9.96E−31
	Cuneus	14q23.1	59625997	rs73313052	DAAM1	Intergenic	18,267	1.90E−32	3.19E−15	2.96E−43
	Cuneus	13q31.1	80191873	rs9545155	LINC01038	Intergenic	18,267	5.15E−10	2.98E−05	3.91E−13
	Pericalcarine	14q23.1	59628679	rs76341705	DAAM1	Intergenic	18,267	4.67E−24	2.56E−19	3.35E−41
		5q12.1	60117723	rs6893642	ELOVL7	Intronic	18,267	1.40E−13	1.68E−08	6.29E−20
		3q13.11	104724787	rs971550	ALCAM	Intergenic	18,267	2.18E−10	1.31E−06	4.49E−15
		6q22.33	127185801	rs9375476	RSPO3	Intergenic	18,267	2.20E−10	2.24E−08	4.32E−17
		1p13.2	113239478	rs2999158	MOV10	Intronic	18,267	6.46E−10	8.39E−10	3.49E−18
		13q31.1	80191873	rs9545155	LINC01068	Intergenic	18,267	7.51E−10	7.53E−09	4.05E−17
	Posterior cingulate	5q12.3	66104105	rs17214309	MAST4	Intronic	18,268	7.84E−11	1.52E−05	4.04E−14
	Insula	10q25.3	118704077	rs1905544	SHTN1	Intronic	17,599	4.06E−12	3.65E−03	1.28E−11

N number of individuals in meta-analysis, p_Discovery two-sided p-value of discovery GWAS meta-analysis in CHARGE, p_Replication two-sided p-value of replication meta-analysis in ENIGMA, p_pooled two-sided p-value of pooled discovery and replication meta-analysis, p-values are not adjusted for multiple comparisons, banksts banks of the superior temporal sulcus.
NA, SNP or region not available in the ENIGMA sample.
In bold: significant replication—p_Replication < 3.1 × 10⁻⁴ (= 0.05/Nl, Nl = 160, total number of lead SNPs).

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Table 2 Genome-wide significant associations (p_Discovery < 1.09 × 10⁻⁹) of global and regional CSA.

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