Fig. 1: Structure, solubility, and pharmacokinetic properties of GSK3008348. | Nature Communications

Fig. 1: Structure, solubility, and pharmacokinetic properties of GSK3008348.

From: Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis

Fig. 1

a The chemical structure of GSK3008348 with full chemical name: (S)-3-(3-(3,5-dimethyl-1H-pyrazol-1-yl)phenyl)-4-(R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic acid). b Docked GSK3008348 (orange) in a homology model of αvβ6 based on αvβ3 X-ray (1L5G) composed of α-subunit (magenta) and β-subunit (gray). c Solubility and key pharmacokinetic properties for GSK3008348 are also shown. SLF, simulated lung fluid.

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