Fig. 5: Response of FRIGHT age and AFRAID clock to interventions.
From: Age and life expectancy clocks based on machine learning analysis of mouse frailty
a–c Frailty Index (FI) score, FRIGHT (Frailty Inferred Geriatric Health Timeline) age and AFRAID (Analysis of Frailty and Death) clock for male 23-month-old C57BL/6 mice treated with enalapril-containing food (280 mg/kg) or control diet from 16 months of age. Data reanalyzed from previously published work21. Control n = 13, Enalapril n = 21. Exact p values, respectively: 0.001, 0.046, 0.29. d–f FI score, FRIGHT age, and AFRAID clock for male 27-month-old C57BL/6 mice treated with either a control diet (0.45% methionine) or methionine-restricted diet (0.1% methionine, MetR) from 21 months of age. *p value <0.05, **p < 0.01, and ***p < 0.001 compared with independent two-sided t-tests. Control n = 11, MetR n = 13. Exact p values, respectively, 0.001, 0.039, 0.006. Error bars represent standard error of the mean. Source data are provided as a Source Data file.
