Fig. 6: Localization of nonmetal implants with postoperative MRI imaging.
From: In vivo localization of chronically implanted electrodes and optic fibers in mice
a The postoperative T2/T1-weighted MRI image shows the tracks of bilaterally implanted optic fibers (magenta arrow, 50-µm core diameter, right hemisphere; white arrow, 105-µm core diameter, left hemisphere). Anatomical landmarks are discernable, including ventricles (blue arrows), the corpus callosum (yellow arrows), and the hippocampal fissure (red arrow). Images from left to right, maximum intensity projection, sagittal slice, horizontal slice, and coronal slice. Yellow numbers refer to the corresponding stereotaxic coordinates in mm relative to Bregma. b Slice-by-slice comparison of the in vivo postoperative MRI images (right) and histology (left, dark-field images overlaid with fluorescent micrographs of nuclear DAPI staining). The corresponding coronal plane of the Paxinos atlas was fitted on the slices marked by white dashed boxes. Scale bar, 1 mm. c High signal-to-noise ratio (SNR) postoperative T2-weighted MRI images were acquired from thick (600-µm) coronal slices from both animals. Numbers indicate the depth of the implant tips relative to the hippocampal fissure in mm. MRI images are shown in goldscale.
