Table 2 Genome-wide significant associations for smoking trajectories in the Million Veteran Program (N = 286,118).
Smoking trajectory | POP | CHR:POS | SNP | EA | NEA | OR | Z | P |
|---|---|---|---|---|---|---|---|---|
Contrast I (current vs. never) | EA | 1: 28717871 | rs61783804 | T | C | 0.94 | −6.12 | 9E − 10 |
1: 28717871 | rs76509406 | T | C | 0.90 | −5.65 | 2E − 08 | ||
1: 73848331 | rs7515828 | C | T | 0.93 | −8.24 | 2E − 16 | ||
2: 45159091 | rs1004787 | A | G | 1.07 | 6.88 | 6E − 12 | ||
2: 104496366 | rs12477780 | T | A | 1.06 | 5.64 | 2E − 08 | ||
2: 146118069 | rs1474011 | A | G | 0.94 | −6.75 | 1E − 11 | ||
4: 152634121 | rs28608075 | C | T | 0.92 | −5.70 | 1E − 08 | ||
6: 26391395 | rs2237235 | A | G | 1.07 | 5.66 | 1E − 08 | ||
6: 27021173 | rs72838268 | A | G | 1.07 | 5.47 | 5E − 08 | ||
7: 117593308 | rs6969783 | T | A | 0.94 | −6.65 | 3E − 11 | ||
8: 27336767 | rs2565060 | A | T | 1.09 | 7.13 | 1E − 12 | ||
9: 136471660 | rs112270518 | G | A | 0.92 | −5.90 | 4E − 09 | ||
11: 112826867 | rs2212450 | T | C | 0.95 | −6.08 | 1E − 09 | ||
11: 113407114 | rs3133388 | G | A | 1.07 | 6.95 | 4E − 12 | ||
14: 33797853 | rs11850899 | C | T | 0.94 | −5.74 | 9E − 09 | ||
15: 47844059 | rs28505872 | C | T | 0.95 | −5.78 | 7E − 09 | ||
16: 69556715 | rs889398 | C | T | 1.05 | 5.64 | 2E − 08 | ||
16: 69953508 | rs4985459 | A | G | 1.06 | 5.77 | 8E − 09 | ||
AA | 1: 4086827 | rs4478781 | C | T | 1.11 | 5.72 | 1E − 08 | |
HA | 6: 73193151 | rs1334346 | A | C | 0.83 | −5.76 | 8E − 09 | |
Contrast II (current vs. mixed) | EA | 5: 11232831 | rs112030805 | A | G | 0.92 | −5.60 | 2E − 08 |
8: 27336978 | rs2565059 | G | A | 1.08 | 7.14 | 9E − 13 | ||
9: 136471660 | rs112270518 | G | A | 0.93 | −5.64 | 2E − 08 | ||
11: 113344912 | rs61902807 | T | C | 1.06 | 6.34 | 2E − 10 | ||
19: 41339896 | rs12459249 | C | T | 0.94 | −7.68 | 2E − 14 |
