Table 1 Quantitative indexes of four models on main cohort data.

Method		AUC	ACC	SENS	SPEC	PPV	NPV	MCC	F1 score
SM	Cross-validation	0.77	0.70	0.77	0.65	0.60	0.81	0.42	0.68
SM	Testing	0.83	0.77	0.72	0.82	0.76	0.78	0.54	0.74
RM	Cross-validation	0.67	0.64	0.68	0.62	0.55	0.74	0.29	0.61
RM	Testing	0.64	0.62	0.71	0.57	0.50	0.76	0.27	0.58
NTLR	Cross-validation	0.81	0.76	0.64	0.85	0.73	0.78	0.50	0.69
NTLR	Testing	0.82	0.79	0.75	0.81	0.73	0.83	0.56	0.74
TLR	Cross-validation	0.96	0.89	0.94	0.85	0.81	0.95	0.78	0.87
TLR	Testing	0.93	0.84	0.94	0.77	0.73	0.95	0.69	0.82

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