Fig. 1: The relationship between sample size and number of identified genes.
From: Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture
Sample size is calculated as the total number of cases and controls under a balanced design (50% cases and 50% controls). Genes associated with LOAD were collected from different studies. They are the closest genes to SNPs (minor allele frequency >0.01) genome-wide significantly (P< 5 × 10−8) associated with LOAD. “Stage 1” means summary statistics based on the samples from stage 1 in that study and “Meta” means summary statistics from the meta-analysis from that study.
