Fig. 2: The prediction performance of genetic risk score (GRS) in different datasets.
From: Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture
a The prediction accuracy of GRSfull based on SNPs selected using different P-value thresholds. GRSfull was calculated based on 1,056,154 HapMap3 SNPs and two APOE SNPs. b The prediction accuracy of GRSno19 based on SNPs selected using different P-value thresholds. GRSno19 is calculated based on HapMap3 SNPs excluding SNPs from chromosome 19, to avoid contamination with APOE. Prediction results on samples from UKB cases and UKB parents are based on summary statistics from Lambert et al.12 (stage 1) only. The error bars represent 95% confidence interval, and the confidence interval was calculated based on 1000 bootstrap replications59.
