Table 2 Kinetic study of Cu2+·ATP.

From: A Cu(II)–ATP complex efficiently catalyses enantioselective Diels–Alder reactions

Entrya

Catalyst

kapp (M−1 s−1)

krel

1

None

(1.6 ± 0.1) × 10−3

1.0

2

ATP

(1.3 ± 0.3) × 10−3

0.8

3

Cu(OTf)2

(1.1 ± 0.1) × 10−2

6.9

4

Cu2+·ATP

(2.0 ± 0.1) × 10−2

12.5

  1. aReaction conditions: 1a (20–50 μM), 2 (5 mM), ATP (250 μM), Cu(OTf)2 (50 μM), MES buffer (2 mL, 20 mM, pH 5.5), 4 °C. All kinetic measurements were performed in triplicate and standard deviations were calculated. The rate acceleration krel was calculated as the ratio of kapp,cat/kapp,uncat, where kapp,uncat and kapp,cat are the kapp values in the absence and presence of the catalyst, respectively.
Back to article page