Fig. 3: Elevated MR ADC distinguishes developmental gene expression programs in high grade meningioma. | Nature Communications

Fig. 3: Elevated MR ADC distinguishes developmental gene expression programs in high grade meningioma.

From: Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma

Fig. 3

a Preoperative T1 post-contrast and apparent diffusion coefficient (ADC) magnetic resonance imaging of spatially distinct regions within meningiomas M7 and M11 demonstrate significant radiologic heterogeneity in high grade meningioma. Black and red circles indicate ADC low and high sample locations, respectively. b WHO grades II and III meningiomas have greater heterogeneity of ADC values than WHO grade I meningiomas. * denotes statistical significance between aggregate ADC values from WHO grade I and WHO grades II and III meningiomas, the latter of which were pooled for analysis. c RNA sequencing reveals 452 differentially expressed genes between ADC low and ADC high regions in WHO grades II and III meningiomas. d, e Gene ontology analysis from RNA sequencing demonstrates that regions with high ADC values in WHO grade II and grade III meningiomas are enriched in Wnt pathway and neuronal development genes, such as CDH2 and PTPRZ1. *P ≤ 0.05, two-tailed Student’s unpaired t test. Mean ± standard error of the mean (as shown by error bars) are denoted for plots in (b, e). Samples from spatially distinct meningioma samples are color-coordinated by tumor-of-origin.

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