Fig. 1: Frequency of characterized genomic alteration from tissue NGS and cfDNA. | Nature Communications

Fig. 1: Frequency of characterized genomic alteration from tissue NGS and cfDNA.

From: Real-world data from a molecular tumor board demonstrates improved outcomes with a precision N-of-One strategy

Fig. 1

a Frequency of characterized genomic alterations by tissue NGS (N = 646) (also see Supplementary Table 1). TP53 was the most commonly altered (52.3% [338/646]) followed by KRAS (23.8% [154/646]), PIK3CA (15.8% [102/646]), APC (13.6% [88/646]) and CDKN2A/B (11.5% [74/646]) alterations. *Percent indicates percent of the patient with alteration. Alterations seen in >3% of patients were included. b Frequency of characterized genomic alterations by cfDNA (N = 309) (See also Supplemental Table 2). The most common alterations were seen in TP53 (48.9% [151/309]) followed by KRAS (22.3% [69/309]), PIK3CA (18.4% [57/309]), BRAF (12.3% [38/309]) and EGFR (12.0% [37/309]) alterations. *Percent indicates percent of the patient with alteration. Alterations seen in >2.5% of patients were included.

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