Fig. 5: EPAS1-oriented regulatory network associates various phenotypes.
From: Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
The EPAS1-oriented network is extracted from vPECA by selecting genes satisfying the conditions: the 1st and 2nd neighbor downstream of EPAS1, differentially expressed genes and enhancers between 0–6 h and 1–3 day (FDR < 0.05) and differentially expressed genes and enhancers between A and W (p-value < 0.05). Rectangles refer to TFs and circles are TGs. Genes with a red border are those with reported selection signals in Tibetan. Colors denote the −log10(p-value) of t-test of gene expression between A and W. Source data are provided as a source data file.
