Fig. 1: POCs and POC nanoaggregates in liposome.

a Crystal structures of FT-RCC3, CC3, CC19, CC1, RCC3, and CC5. b Structure of window-to-window packing of tetrahedral POCs. c Side view of a tetrahedral POC crystal (gray with red vertex group) with channel network (blue) shown. Ends of the channel network (yellow) are possible entry points for guest molecules. d Structure of an extended channel network without tetrahedral POC shell. The tetrahedral 3D channels run through cage cavities and inter-cage gaps with the node at the center of the cage cavity. e Scheme of CC3 nanoaggregates (light blue) in lipid bilayer with water chains formed inside the channels. Insert: CC3 molecules shown in blue with the water channel illustrated in gray. Fluorescence confocal microscopy of liposomes with CC5 (f) and CC19 (g) under an excitation of 402 nm laser. Blue circles indicate the presence of CC5 and CC19 in the lipid bilayer. Scale bar represents 5 μm.