Fig. 3: Glial activation and α-syn aggregation in SNCA-OVX mice.
From: CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease
a, c, e Representative images of immunofluorescence of GFAP (astrocytes), IBA1 (microglia), and AS-PLA in dopaminergic neurons, respectively. Scale bars = 200, 25, and 25 µm, respectively. b, d, f Quantification of normalized stained area, morphology (expressed as a % from total), and puncta per TH+ cell analyzed using a two-way ANOVA (Dunnett’s for age and Sidak’s for genotype, for age all values compared to 3 months), n = 3–4 animals per group. b F(3, 20) = 1.211, p = 0.0177 for age and F(1, 20) = 0.1572, p = 0.0106 for genotype. d F(1, 22) = 2.216, p = 0.0287 for genotype and F(3, 22) = 1.764, p = 0.0209, p = 0.0104, p = 0.0192 for age. f F(3, 21) = 4.528 for age, p = 0.0058, p = 0.0016, p = 0.0024 and F(1, 21) = 33.41, p = 0.0043, p = 0.0015, p = 0.0061 for genotype. *p < 0.05. For all appropriate panels, data are presented as mean values ± SEM. OVX: SNCA-OVX.
