Fig. 3: Transcriptional and DNA methylation profiles of the epithelial and sarcomatoid components. | Nature Communications

Fig. 3: Transcriptional and DNA methylation profiles of the epithelial and sarcomatoid components.

From: Integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma

Fig. 3

a The heatmap of hierarchical clustering with the expression level of a 76-gene EMT signature, annotated for the histological type and the patients. AT, adenocarcinoma component; SCCT, squamous cell carcinoma component; ST, sarcomatoid component. Source data are provided as a Source data file. b EMT scores are plotted for adenocarcinoma (AT), squamous cell carcinoma (SCCT), and sarcomatoid (ST) components as boxplots. Center line, median; box limits, upper and lower quartiles; whiskers, 1.5× interquartile range; colored points, outliers. Two-sided Wilcoxon rank-sum test was used for statistical analysis. No P-value adjustment was applied. n = 7, 7, and 14 for AT, SCCT, and ST group, respectively. Source data are provided as a Source data file. c The heatmap of hierarchical clustering with DNA methylation data of the epithelial and sarcomatoid components, annotated for the histological type and the patients. AT, adenocarcinoma component; SCCT, squamous cell carcinoma component; ST, sarcomatoid component. d The mean expression levels and DNA methylation levels of the 26 genes in the epithelial and sarcomatoid components. M (mesenchymal) markers and E (epithelial) markers are displayed in the upper and lower panel, respectively. S and E in the bottom represent sarcomatoid and epithelial components. Source data are provided as a Source data file.

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