Fig. 5: Integrated molecular classification of PSC. | Nature Communications

Fig. 5: Integrated molecular classification of PSC.

From: Integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma

Fig. 5

a PSC tumors are classified into subgroups based on DNA methylation patterns, annotated for the mutation status (Mut, mutated; WT, wild-type) of important genes, TNM stage, smoking status, and histological subtype in the top panel and for the immunohistochemical analysis of PD-L1 and CD8 in the bottom panel. b Kaplan–Meier analysis of C1, C2, and C3. The significance is determined by log-rank test. c Boxplot shows the expression level of TP63 for three clusters. d Leukocyte fraction of each sample for three clusters are plotted as boxplots. Center line, median; box limits, upper and lower quartiles; whiskers, 1.5× interquartile range; colored points, outliers. Two-sided Wilcoxon rank-sum test was used for statistical analysis of (c) and (d). No P-value adjustment was applied. PD-L1, programmed death ligand 1; CD8, cluster of differentiation 8; TP63, tumor protein 63.

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