Fig. 1: Evaluation of the association between irAE and related factors.
From: Multi-omics prediction of immune-related adverse events during checkpoint immunotherapy
a Anatomic sites of cancer types (left panel), and irAE ROR across 26 cancer types (right panel). b Spearman correlation between irAE ROR and 36 factors for positive correlation (red lollipop) and negative correlation (blue lollipop). * indicates significant correlation (FDR < 0.05); cytolytic activity FDR = 0.01, Interferon (IFN) γ signature FDR = 0.01, PD-1 FDR = 0.01, T-cell receptor (TCR) diversity FDR = 0.01, macrophages M1 FDR = 0.03, CD8+ T cells FDR = 0.05, naive B cells FDR = 0.05; irAE and immune therapy response-related factors are marked in orange. c Comparison of performance of bivariate models in predicting irAE for all combinations of six significantly correlated variables. Spearman R (Rs) was calculated between predicted and observed irAE ROR. The shade of the square indicates the Rs, and the size indicates the significance of the log-likelihood ratio test. d Combined effect of TCR diversity and CD8+ T-cell bivariate model (Spearman correlation, Rs = 0.75, FDR = 8.24 × 10−4). The equation of the bivariate model is 0.31 × TCR diversity + 8.87 × CD8+ T cells + 0.27. irAE immune-related adverse events, ROR reporting odds ratio, FDR false discovery rate, LUAD lung adenocarcinoma, SKCM skin cutaneous melanoma, LUSC lung squamous cell carcinoma, KIRC kidney renal clear cell carcinoma, PRAD prostate adenocarcinoma, BLCA bladder urothelial carcinoma, MESO mesothelioma, BRCA breast invasive carcinoma, CESC cervical squamous cell carcinoma and endocervical adenocarcinoma, UCEC uterine corpus endometrial carcinoma, SARC sarcoma, ESCA esophageal carcinoma, PAAD pancreatic adenocarcinoma, OV ovarian serous cystadenocarcinoma, HNSC head and neck squamous cell carcinoma, STAD stomach adenocarcinoma, THCA thyroid carcinoma, CHOL cholangiocarcinoma, ACC adrenocortical carcinoma, READ rectum adenocarcinoma, COAD colon adenocarcinoma, LIHC liver hepatocellular carcinoma, LGG brain lower-grade glioma, GBM glioblastoma multiforme, UVM uveal melanoma, UCS uterine carcinosarcoma.
