Fig. 4: Network profiles between microbial taxa and stool metabolite components in non-obese and obese subjects. | Nature Communications

Fig. 4: Network profiles between microbial taxa and stool metabolite components in non-obese and obese subjects.

From: Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

Fig. 4

Co-occurrence coefficients among family-level microbiome components and stool metabolites were calculated by SparCC, and networks (P < 0.05) are depicted using Cytoscape. a Non-obese and b obese. The solid line (orange) and dotted line (gray) indicate positive and negative correlations, respectively. The shape of the node denotes the components used in this study (ellipse: microbiome, diamond: stool bile acids, and round rectangle: SCFAs) and the color indicates the degree of correlation with fibrosis severity. The P-value for each coefficient was obtained by bootstrapping the dataset 500 times and applying SparCC to each of those 500 datasets. Source data are provided as a Source Data file.

Back to article page