Fig. 2: Subclones from distinct lineages can be spatially intermixed within the prostate. | Nature Communications

Fig. 2: Subclones from distinct lineages can be spatially intermixed within the prostate.

From: Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy

Fig. 2

Six samples were collected across two tissue blocks from adjacent regions of the prostate. The intra-prostatic portion of the phylogenetic tree of A31 is shown, with lines denoting the final subclone of each distinct lineage found in the corresponding regions in each slide. Numbered subclones in yellow circles correspond to the clusters shown in Supplementary Fig. 8. Subclones that correspond to over 50% of tumor cells in a region are designated high proportion, all other subclones present are low proportion. Location of slides are given in Supplementary Fig. 13.

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