Fig. 2: Reclustering of myeloid-derived cells (LYZ+). | Nature Communications

Fig. 2: Reclustering of myeloid-derived cells (LYZ+).

From: Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma

Fig. 2

a tSNE plot of subgroups of LYZ+ single cells. b DEGs between monocytes and TAMs. Single cells in red blank show features of both groups. c Trajectory of differentiation from monocyte into TAMs predicted by monocle 2. d Significantly inhibited or activated TF motifs in the differentiation process colored by cell clusters. e Heatmap show upregulated or downregulated immune checkpoints in the differentiation process. f Heatmap of DEGs between three different DC subgroups. g Violin plot show expression level of cytokines and CD274 highly expressed in LAMP3+ DCs. h Correlation between LAMP3+ DCs and different T cell subgroups in TCGA BLCA cohort. Coefficient was calculated with spearman correlation analysis.

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