Fig. 1: Mammary epithelium-specific CTSD deficiency delays tumor development in PyMT mice. | Nature Communications

Fig. 1: Mammary epithelium-specific CTSD deficiency delays tumor development in PyMT mice.

From: Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling

Fig. 1

a Representative pictures of whole mounts of mammary glands from 8-week-old PyMT mice of indicated genotypes (Control: Ctsdfl/fl). Areas occupied by dysplastic lesions are encircled in red and quantified in b (n = 5 animals; two-sided two-sample t-test). LN, lymph node. c Kaplan–Meier analysis for first palpable tumors in PyMT mice of indicated genotypes (Controls: 4× Ctsd+/fl + 8× Ctsdfl/fl; *, two-sided log-rank test compared with controls). d Representative pictures and e quantification of volumetric ultrasound imaging of the two largest tumors detected per individual in 18-week-old PyMT mice of indicated genotypes (Controls: 2x Ctsd+/fl + 8x Ctsdfl/fl; n = 10 animals; two-sided Mann–Whitney test). f Kaplan–Meier analysis for tumors at end-stage (1 cm3) in PyMT mice of indicated genotypes (Controls: 4× Ctsd+/fl + 8x Ctsdfl/fl; *, two-sided log-rank test compared with controls). Bar charts show all data points with mean + SD and p-value. Source data are provided as a Source Data file.

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