Table 1 Re-growing CTSD-deficient tumor cells upregulate oncogenic signaling pathways.

From: Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling

Downregulated

FDR

Tight junction

1.90E−04

Arginine and proline metabolism

1.25E−02

Upregulated

FDR

Pathways in cancer

3.75E−06

Rap1 signaling pathway

1.18E−05

Focal adhesion

1.51E−05

PI3K-Akt signaling pathway

2.65E−05

ECM-receptor interaction

1.30E−04

AGE-RAGE signaling pathway in diabetic complications

5.20E−04

Axon guidance

5.70E−04

Relaxin signaling pathway

6.30E−04

MAPK signaling pathway

7.90E−04

Ras signaling pathway

1.40E−03

  1. Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) -based KEGG pathway enrichment analysis on transcripts expressed and significantly regulated (1066 down, 1429 up) in Ctsd−/− PyMT cells cultured for ≥8 weeks in 1% FCS medium (1% FCS LT) compared to 1% FCS Ctsd−/− PyMT cells and corrected for long-term 1% FCS culture effects in Ctsd+/+ PyMT cells (n = 3). Top 10 pathways with false discovery rate (FDR).
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