Fig. 7: Abnormal HFO PAC and aberrant synchrony below 100 Hz characterize EZ contacts.
From: Long-range phase synchronization of high-frequency oscillations in human cortex
a Cross-frequency phase-amplitude coupling (PAC) among SEEG contacts outside of the epileptogenic zone (nEZ–nEZ). PAC was evaluated with PLVPAC and here illustrated as normalized PAC, nPAC = PLVPAC,observed/PLVPAC,surrogate, so that nPAC > 1 indicates PAC above the null hypothesis level. Extent of coupling measured as the fraction of significant edges exhibiting PAC (K) is reported in Supplementary Fig. 3c. b PAC among contacts in the epileptogenic zone (EZ–EZ) and c between the putatively healthy and epileptogenic contacts (EZ–nEZ). d Synchronization among EZ–EZ (red) and nEZ–nEZ (blue) contact pairs in 20 bins of inter-contact distances for frequency ranges from delta to HGA (top to bottom panels). Shaded areas indicate the 5 and 95%-ile of mean PLV of bootstrap observations (Nbootstraps = 104, markers denote the frequencies with a significant (p < 0.05, one-sided randomization test with Benjamini–Hochberg correction) difference between EZ–EZ and nEZ–nEZ PLV values, solid makers denote differences that are significant after Benjamini–Hochberg FDR correction for multiple comparison).
