Fig. 2: FGFR1 kinase alterations and ALK N-terminal structural alterations.
From: Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations
a Positions of point mutations in FGFR1 in six patients, including 5 SNVs at N546K and an ITD in the kinase domain (duplicated region in green). IG indicates the extracellular immunoglobulin-like domain (blue), while the intracellular kinase domain is shown in red. Exon boundaries are indicated by dotted lines. b ALK protein structure with protein domains indicated by color. Dotted lines indicate exon boundaries. The five samples with ALK N-terminal structural alterations are shown, with the lost exons indicated in purple. MAM indicates Meprin A5 and tyrosine phosphatase Mu domain; LDLa indicates low-density lipoprotein receptor domain class A domain; FXa indicates coagulation factor Xa inhibitory site domain.
