Fig. 3: Tc2, Tc17, and Tc22 CD8+ T-cell subsets possess helper characteristics.
From: SLAMF7 and IL-6R define distinct cytotoxic versus helper memory CD8+ T cells
a Heatmap representation of normalized, log2-transformed RNA-Seq expression values of selected genes. b, c Perforin and granzyme B (b) or CLA (c)-expressing cells among resting CD45RA−CD8+ (black circles) and CD4+ (gray circles) T-cell subsets (n = 6), mean ± SEM. d CD40L-expressing cells among sorted and polyclonally activated Tc- (black circles) and Th- (gray cicrcles) cell subsets (n = 8), mean ± SEM. e Frequencies of IL-17+ and IL-13+ cells among splenocyte derived CD40L− (black circles) or CD40L+ (gray circles) dump −CD3+CD44+CD8+ memory T cells from pet shop mice after polyclonal activation. Mean ± SEM. Student’s t test. *P < 0.05, **P < 0.01, ***P < 0.001.
