Fig. 6: Increased fasting glucose levels in PCOS overall cannot be ameliorated by dietary interventions.
From: Defining the impact of dietary macronutrient balance on PCOS traits
a Fasting glucose levels, showing a significant increase in basal glucose levels in PCOS mice compared to control mice (P = 0.04). Significance determined by Mann–Whitney test, asterisk (*) indicates P-value <0.05. Data presented as violin plots, doted lines indicate the median and dashed lines the 25 and 75% percentiles. b–g 3D GAM response surfaces displaying the relationship between macronutrient intake (kJ/day) and glucose levels in control (b–d) and PCOS mice (e–g). Red areas indicate the greatest value for each response, which then decreases to the lowest value as the color shifts to blue. Control mice exhibited a decrease in fasting glucose with increasing fat intake while PCOS mice display overall increased levels of fasting glucose. h–j Response surfaces showing the effects of C and F intakes on fasting glucose levels in control mice (h), PCOS mice (i) and response difference (j), demonstrating that fasting glucose levels in PCOS mice are comparable to control mice when fat intake was reduced to <12 kJ/day. On the other hand, fasting glucose is not able to be modulated by diet when PCOS mice ingested F in the range of 12–32 kJ/day, indicating that PCOS pathology hinders serum fasting glucose levels in PCOS mice with higher F intakes. a–j n = 93 control and 94 PCOS mice.
