Table 1 Temporal drug combinations.
From: Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids
Combinatorial chemotherapy | Constant drug combination description | Temporal drug combination description | Temporal delivery description |
|---|---|---|---|
FOLFIRINOX | CPT-11 (100 nM), Oxaliplatin (100 nM), Fluorouracil (100 nM) | CPT-11 (100 nM), Oxaliplatin (100 nM), High Dose Fluorouracil (1 μM), Low-Dose Fluorouracil (100 nM) | CPT-11 (2 h), Oxaliplatin (2 h), High Dose Fluorouracil (30 min), Low-Dose Fluorouracil (48 h) |
FOLFIRI | CPT-11 (100 nM), Fluorouracil (100 nM) | CPT-11 (100 nM), High Dose Fluorouracil (1 μM), Low-Dose Fluorouracil (100 nM) | CPT-11 (4 h), High Dose Fluorouracil (30 min), Low-Dose Fluorouracil (48 h) |
FOLFOX | Oxaliplatin (100 nM), Fluorouracil (100 nM) | Oxaliplatin (100 nM), High Dose Fluorouracil (1 μM), Low-Dose Fluorouracil (100 nM) | Oxaliplatin (4 h), High Dose Fluorouracil (30 min), Low-Dose Fluorouracil (48 h) |
Gemcitabine and Fluorouracil (5-FU) | Gemcitabine (100 nM), Fluorouracil (100 nM) | Gemcitabine (100 nM), Fluorouracil (100 nM) | Gemcitabine (4 h), Low-Dose Fluorouracil (48 h) repeated twice |
Gemcitabine and Paclitaxel | Gemcitabine (100 nM), Paclitaxel (10 nM) | Gemcitabine (100 nM), Paclitaxel (10 nM) | Gemcitabine (4 h), Paclitaxel (4 h), normal growth media (24 h) repeated twice |
