Fig. 3: Functional properties of encapsulin-produced magnetic iron oxide nanocomposites (eMIONs).
From: Genetically engineered magnetic nanocages for cancer magneto-catalytic theranostics
a Alternative magnetic field (AMF) induced temperature rise. Data are presented as mean ± SD (n = 5 independent experiments). b Comparison of SAR values of eMIONs to fMIONs and two types of commercial agents. c T2-weighted MR images and T2 relaxation rates (1/T2, s−1) of eMIONs and fMIONs at different iron concentrations. d Schematic illustration of eMIONs for enhancing catalysis under AMF. e–g The relative dissolved O2 in H2O2 (100 μM) after incubation of various concentrations of eMIONs and fMIONs (e, pH 6.8), various pH solutions (f), and various temperatures (g, 1 = 25 °C, 2 = 37 °C, 3 = 43 °C). Data are presented as mean ± SD (n = 5 independent experiments). Tukey boxplots are shown with the box indicating quartiles and the whiskers drawn at the lowest and highest points within 1.5 interquartile range of the lower and upper quartiles, respectively. Error bars show the 95% confidence interval for the difference in proportions or medians between the O2 production. h, i H2O2 (100 μM) decomposition by catalase-like activity of eMIONs with oxygen generation measured by the level of dissolved oxygen (h) and Michaelis–Menten kinetics (i) of eMIONs/fMIONs with/without AMF.
