Table 1 Next-generation whole-exome sequencing.

From: Combating acquired resistance to MAPK inhibitors in melanoma by targeting Abl1/2-mediated reactivation of MEK/ERK/MYC signaling

Resistant cell lines

MAPK pathway mutations

M14-BR

NRAS-Q61R

Mel1617-BR

MAP2K1-Q60P

451-Lu-BR

MAP2K7-P68A

M14-BMR

MAP4K1-P422Q

  1. MAPK pathway acquired mutations in resistant lines that are not present in parental lines. See Supplementary Data Files 1 and 2 for complete gene lists.
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