Table 2 Association trend of WMH risk loci with white matter microstructures in young adults.

Variables	Region	Nearest gene	PSMD (10⁻⁴ mm²s⁻¹)			FA			MD (10⁻⁴ mm²s⁻¹)			RD (10⁻⁴ mm²s⁻¹)			A_xD (10⁻⁴ mm²⁻¹)
Variables	Region	Nearest gene	Β	SE	P	β	SE	P	β	SE	P	β	SE	P	β	SE	P
wGRS			0.077	0.022	4.53E-04	−0.012	0.002	2.53E-07	0.111	0.026	1.66E-05	0.142	0.028	5.38E-07	0.050	0.031	1.09E-01
SNPs^a
rs10786772	10q24.33	SH3PXD2A	0.019	0.005	9.98E-05	−0.002	0.001	3.70E-04	0.022	0.006	1.11E-04	0.025	0.006	7.16E-05	0.017	0.007	1.86E-02
rs6503417	17q21.31	NMT1	0.015	0.005	2.25E-03	−0.002	0.001	2.20E-03	0.021	0.006	1.52E-04	0.023	0.006	2.13E-04	0.018	0.007	7.06E-03
rs830179	3q27.1	KLHL24	0.012	0.005	1.52E-02	−0.001	0.001	8.81E-02	0.014	0.006	1.32E-02	0.014	0.006	2.56E-02	0.015	0.007	2.94E-02
rs17205972	5q14.2	VCAN	0.030	0.006	3.28E-07	−0.004	0.001	2.29E-09	0.041	0.007	1.80E-09	0.049	0.008	1.20E-10	0.027	0.008	1.23E-03

All models are adjusted for age, sex, the first four principal components for population stratification, and total intracranial volume.
PSMD peak width of skeletonized mean diffusivity, FA fractional anisotropy, MD mean diffusivity, RD radial diffusivity, A_xD axial diffusivity, β effect estimate, SE standard error, P P value, wGRS weighted Genetic Risk Score, SNP single nucleotide polymorphism.
^aFor individual SNPs, a p value < 2 × 10⁻³ is considered significant, after multiple testing correction (considering 25 independent loci tested).

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