Fig. 8: Parallel evolution of RAS/PTPN11 clones during FLT3 inhibitor-containing therapy.
From: Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics
A 58-year-old-man with refractory AML showing the clearance of FLT3-ITD clone with an expansion of PTPN11/RAS clones during a FLT3 inhibitor-containing therapy. The fish plot shows the inferred clonal evolution pattern based on the single-cell genotype data. The phylogenetic trees visualize the estimated order of mutation acquisition and the proportion of subclones with a different combination of mutations at each timepoint. The wild-type cells which did not carry any driver mutations are not shown. C cycle, D day, ADO allele dropout, FPR false-positive rate. Full case description is available in Supplementary Methods.
