Fig. 2: Temporal reliability is affected in mice with either dysmyelination or an oligodendrocyte-specific metabolic impairment. | Nature Communications

Fig. 2: Temporal reliability is affected in mice with either dysmyelination or an oligodendrocyte-specific metabolic impairment.

From: A role of oligodendrocytes in information processing

Fig. 2

a Schematic of the click-rate-tracing protocol used to test temporal reliability. Blocks of ten clicks are played at different rates in random order. Each rate is repeated ten times. Analysis in c focuses on the highlighted (yellow) clicks 1, 5, and 10 (c1, c5, and c10). b Example raster plot of ACx responses (each dot = 1 spike) to ten clicks at 5 Hz across the ten stimulus repetitions in a Wt (upper, black) and an Mbpshi/shi mouse (lower, red). Mbpshi/shi animals show a steeper decay on spiking activity across clicks compared to Wt. c Mean peristimulus time histogram (PSTH) of responses to clicks 1, 5, and 10, at 5 Hz for Wt (black, n = 10) and Mbpshi/shi (red, n = 13) animals. The thick line shows the mean of all recorded animals and the shaded area depicts the S.E.M. Click onset is indicated by dashed lines. While responses to the first click are similar in amplitude in Wt and Mbpshi/shi animals (with the expected delay in Mbpshi/shi), a strong reduction of response strength is seen in Mbpshi/shi mice with increasing clicks. d Individual examples of spike synchrony plots for Wt (black, top) and Mbpshi/shi (red, bottom) were taken from the first sliding window (see panel e clicks 2–5). Syn: synchrony %, sc: spike count. e Quantification of spike synchrony in sliding windows of four clicks (clicks 2–5, 3–6, 4–7, 5–8, 6–9, and 7–10). Onset responses to click 1 were excluded. Leftmost: significant reduction in spike synchrony between Mbpshi/shi mice (red, n = 11) and Wt (black, n = 5 mice) at 5 Hz (one-way ANOVA, F(1,76) = 10.17, P = 0.002). Middle: significant reduction also seen between Mbpneo/neo mice (orange, n = 6 mice) and Wt (black, n = 8 mice) at 5 Hz (one-way ANOVA, F(1,86) = 10.94, P = 0.0014). Right: significant difference between Mct1+/− mice (purple, n = 6 mice) and Wt (black, n = 8 mice) at 2 Hz (one-way ANOVA, F(1,78) = 6.74, P = 0.011). Source data are provided as a Source Data file.

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