Fig. 3: Cortical temporal acuity is severely impaired with central nervous system (CNS) dysmyelination and partially impaired upon axoglial metabolic reduction. | Nature Communications

Fig. 3: Cortical temporal acuity is severely impaired with central nervous system (CNS) dysmyelination and partially impaired upon axoglial metabolic reduction.

From: A role of oligodendrocytes in information processing

Fig. 3

a Temporal acuity test: gap-detection protocol. A pregap broadband noise (BBN, 200 ms) followed by a silent gap (0–50 ms, ten repetitions each) and post-gap BBN (50 ms). b Example for Wt (upper, black) and Mbpshi/shi (lower, red): sound-evoked (gray patch) ACx spikes (dots) before/after gaps of 0-ms (left), 2-ms (center), and 10-ms (right) length, across ten repetitions. c Same as in b for the Mct1 (purple). d Average peristimulus time histogram (PSTH) for Wt (black, n = 12) and Mbpshi/shi (red, n = 14). Left to right: pregap responses followed by post-gap responses for 0.5–5-ms gaps. Effect of group for post-gap, but not pregap, responses (two-way ANOVAs [F(1,462) = 0.53, P = 0.46], [F(1,502) = 24.47, P = 1.03 × 10−6], [F(1,502) = 20.48, P = 7.54 × 10−6], [F(1,502) = 24.06, P = 1.26 × 10−6], [F(1,502) = 14.38, P = 0.0002], and [F(1,502) = 7.62, P = 0.006]. e Quantification of significance (median p value between baseline and post-gap response/recording, see inset). Lower detection in Mbpshi/shi (red, n = 20 sites, 14 animals) than Wt (black, n = 15 sites, 12 animals) for short gaps, group effect (two-sided Kruskal–Wallis, F(1,214) = 15.81, P = 7 × 10−5). Dotted line: threshold at 0.05. Yellow shadow: significant gap detection. f Same as d for Mct1+/− (purple, n = 6) and Wt (black, n = 8). Group effect for all responses (two-way ANOVAs [F(1,252) = 30.06, P < 0.0001], [F(1, 313) = 24.42, P = 1.26 × 10−6], [F(1,313) = 15.74, P = 9.02 × 10−5], [F(1,313) = 36.65, P = 4.03 × 10−9], [F(1,313) = 10.53, P = 0.001], and [F(1,313) = 21.3, P = 5.73 × 10−6]. g Same as e for Mct1+/− mice (purple, n = 9 sites, six animals) and Wt mice (black, n = 13 sites, eight animals). Group effect (two-sided Kruskal–Wallis, F(1,151) = 8.83, P = 0.0027). d, f Dotted lines: sound onset and offset. e, g Circles: median/group/gap length, and error bars: S.E.M. Source data are provided as a Source Data file.

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