Fig. 4: Complete kinetic model for the pol-to-exo mode transition connecting all on-path intermediates identified by the MEMM analysis.
From: Polymerization and editing modes of a high-fidelity DNA polymerase are linked by a well-defined path
Macrostates S1–S8 are denoted by circles. Larger circles correspond to more populated macrostates. Transition between states are indicated with arrows and computed timescales for transitioning in and out of each macrostate are shown above the arrows. Each microstate is also represented by a cartoon, indicating the position and the extent of unpairing of the DNA primer end. The position of the mismatch nucleotide on the primer strand is indicated by a yellow star.
