Table 1 SEARCHIN-based prioritization of candidate ligand–receptor interactions.

1

Nme1-Ptprn

0.005189

2

Cdh2-Ryk

0.006011

3

App-Tnfrsf21

0.006891

4

Lgals1-Spn

0.016729

5

Crk-Tgfbr2

0.016729

6

App-Adgrl1

0.016729

7

App-Glrb

0.018234

8

Ccn2-Itgb5

0.018798

9

Cnbp-Rap1a

0.021792

10

B2m-Osmr

0.021792

11

Cxcl5-Cx3cl1

0.023618

12

Ccl3-Cx3cl1

0.025303

13

Igf1-Itsn1

0.027218

14

Hmox1-Itgb2

0.030239

15

Hp-Itgb2

0.031028

16

Mapre1-Rab35

0.033395

17

B2m-Tgfbr2

0.033395

18

App-Ryk

0.033395

19

Crk-Rras

0.036937

20

Cdh2-Glrb

0.038753

21

Cst3-Hbegf

0.042941

22

Crk-Ephb3

0.043552

23

Cdh2-Lingo1

0.047665

24

Crk-Arhgap17

0.049999

25

Sod1-Tgfbr2

0.049999

26

Crk-Ryk

0.049999

27

Cdh2-Itgb1

0.050914

28

Crk-Itsn1

0.050914

29

App-Tgfbr2

0.054627

30

App-Lingo1

0.057122

31

Cdh2-Grik2

0.066541

32

Mapre1-Ryk

0.066541

33

Ccn2-Tgfbr2

0.066541

34

Cdh2-Itpr3

0.068034

35

Igfbp5-Rras

0.077874

36

App-Homer3

0.083021

37

Ltbp2-Tgfbr2

0.083021

38

Cfl1-Mark2

0.0839

39

Lgals3-P2ry12

0.087964

40

Ccn2-Itgb1

0.090229

41

Igf1-Il31ra

0.09107

42

B2m-Bcl10

0.09186

43

B2m-Cdh13

0.09186

44

B2m-Cd48

0.094226

45

Sod1-Sri

0.099439

46

Ccn2-Hbegf

0.100684

47

App-Mast1

0.103987

48

Hmox1-Rab3d

0.107428

49

Cst3-Furin

0.111111

50

Pdia3-Atp6ap2

0.115796

51

Gaa-P2rx4

0.121222

52

App-Rgs14

0.122663

53

B2m-Itgb1

0.130793

54

App-Homer2

0.132091

55

B2m-Treml1

0.132091

56

App-Gria1

0.132091

57

Crk-Pdgfra

0.135862

58

Lgals1-Cx3cl1

0.135862

59

Lgals1-Rhoc

0.139274

60

App-Akt1

0.148324

61

App-Grik3

0.148324

62

App-Gabrb1

0.148324

63

Crk-Kitl

0.152671

64

Cfl1-Kitl

0.154985

65

Igf1-Kitl

0.157321

66

Cfl1-Rras

0.159681

67

Crk-Rap1a

0.164471

68

App-Diras1

0.164496

69

App-Il31ra

0.164496

70

Hnrnpk-Itgb1

0.169356

71

B2m-Il31ra

0.180607

72

Crk-Diras1

0.180607

73

Cdh2-Itgb2

0.181989

74

Lgals1-Atp6ap2

0.184178

75

B2m-Hbegf

0.187214

76

App-Arhgap17

0.195236

77

Cfl1-Iqgap1

0.196657

78

App-Cap2

0.196657

79

Crk-Pdgfrb

0.197253

80

Igf1-Itk

0.200709

81

Igf1-Rhoh

0.200709

82

Crk-Cyth3

0.200709

83

Hnrnpk-Itk

0.203484

84

B2m-Tnfsf13b

0.206185

85

B2m-Tnfsf12

0.20911

86

Cdh2-Itsn1

0.20911

87

App-Itgb1

0.212645

88

App-Gria3

0.228573

89

Crk-Itgb1

0.228573

90

Pdia3-Plxna1

0.24444

91

Cst3-Itgb1

0.24444

92

Crk-Rasl10a

0.24845

93

B2m-Glrb

0.253351

94

B2m-Cx3cl1

0.254645

95

Crk-Ghr

0.258292

96

Crk-Dok3

0.260246

97

Crk-Mast1

0.260246

98

App-Itgb5

0.263273

99

App-Rab3d

0.271175

100

Lgals1-Ptprc

0.275992

101

Crk-Elmo1

0.278453

102

Igfbp5-Ager

0.283591

103

B2m-Ghr

0.284903

104

Cst3-Ghr

0.288406

105

Nme2-Rab5a

0.291677

106

App-Dgkz

0.291677

107

Crk-Csf1

0.295497

108

App-Mas1

0.299237

109

Arcn1-Rab18

0.304528

110

B2m-Cd79b

0.306351

111

Myl12b-Sri

0.307302

112

Crk-Dgkz

0.307302

113

Crk-Gab2

0.309858

114

App-Rhoq

0.315225

115

B2m-Rhoq

0.320629

116

App-Itsn1

0.320629

117

App-Csf1

0.322867

118

App-Rab39b

0.322867

119

Crk-Rhoq

0.32607

120

Cfl1-G3bp1

0.332704

121

Crk-Rhoc

0.332704

122

Crk-G3bp1

0.336587

123

App-Dlg4

0.338371

124

B2m-Csf1

0.338371

125

Crk-Rab39b

0.338371

126

Crk-Rgs20

0.340501

127

Igfbp5-Prkca

0.342614

128

Crk-Rhod

0.342614

129

B2m-Itgb2

0.348201

130

Crk-Rab3d

0.348419

131

Cdh2-Sipa1l1

0.352424

132

Crk-Ptk2b

0.353816

133

Igfbp5-Pdgfra

0.353824

134

Cfl1-Sipa1l1

0.356459

135

Igfbp5-Pdgfrb

0.365178

136

Mapre1-Rock2

0.3692

137

App-Itpr3

0.3692

138

App-Anxa1

0.376672

139

Arcn1-Dnm2

0.38132

140

Crk-Dnm2

0.385573

141

Igf1-Pdgfra

0.388305

142

App-Rras

0.388305

143

App-Dnm2

0.389857

144

Crk-Gem

0.389857

145

Cst3-Dner

0.394173

146

App-G3bp1

0.39852

147

Cst3-Il6ra

0.399791

148

App-Cx3cl1

0.399791

149

App-Apbb1ip

0.399791

150

Cdh2-Celsr2

0.400075

151

Ccn2-Sri

0.411754

152

Cst3-Itgb3

0.414997

153

Pdia3-Sri

0.416229

154

Hp-Sri

0.420737

155

B2m-Cd3e

0.424019

156

Hmox1-Sri

0.425278

157

Sod2-Sri

0.42985

158

Cfl1-Sdcbp

0.42985

159

App-Nod1

0.430143

160

Arcn1-Sdcbp

0.434456

161

Crk-Rab40b

0.434456

162

Crk-Sdcbp

0.439094

163

App-Rab40b

0.439094

164

App-Ephb3

0.442324

165

Pdia3-Sdcbp

0.443765

166

Cdh2-L1cam

0.44523

167

Igf1-Nod1

0.44523

168

Crk-Rasgrp1

0.453207

169

App-Gabra4

0.453207

170

Crk-Fcgr2b

0.462781

171

B2m-Fcgr2b

0.467619

172

B2m-Ifnar2

0.47249

173

App-Aplp2

0.47249

174

Nme2-Tbxa2r

0.475227

175

Cst3-Pdgfra

0.479796

176

B2m-Cd274

0.482333

177

Hp-Itgam

0.482333

178

Cfl1-Rab11a

0.486151

179

Crk-Fgfr1

0.490137

180

Igf1-Pdgfrb

0.497353

181

Cfl1-Rab10

0.504989

182

App-Adrb1

0.504989

183

Lgals3-Lpar1

0.511872

184

Mapre1-Mib1

0.519781

185

B2m-Arhgap10

0.533604

186

App-Slc7a1

0.534515

187

Crk-Arhgap10

0.538922

188

App-Arrb1

0.544276

189

Cdh2-Ddr1

0.549191

190

App-Hbegf

0.549191

191

Arcn1-Rab11a

0.551339

192

Hmox1-Ptprc

0.558017

193

App-Mark2

0.563808

194

Cdh2-Ptprc

0.564723

195

B2m-Inpp5d

0.564723

196

App-Gpr12

0.566044

197

Cst3-Inpp5d

0.571457

198

B2m-Ptprc

0.571457

199

Crk-Mark2

0.578367

200

Crk-Rras2

0.582746

201

App-Itga6

0.598666

202

Hnrnpk-Homer2

0.599774

203

App-Rhoj

0.60731

204

App-Kcnk2

0.60731

205

Crk-Grasp

0.61243

206

Crk-Rhoj

0.621695

207

Crk-Mras

0.622988

208

Crk-Rab14

0.6263

209

App-Il1rl1

0.628884

210

Arcn1-Rab14

0.633273

211

B2m-Il1rl1

0.634817

212

Hnrnpf-Rab14

0.640272

213

Igf1-Il1rl1

0.640787

214

Nme1-Rrad

0.650291

215

App-Adam9

0.654345

216

B2m-Gabra4

0.658921

217

B2m-Sdcbp

0.665041

218

Crk-Rab11a

0.668517

219

Crk-Rasa4

0.671199

220

App-Grm5

0.67564

221

App-Gabra2

0.678658

222

App-Cdh13

0.689957

223

App-Bcl10

0.689957

224

B2m-Gabra2

0.692755

225

Cfl1-Traf4

0.69621

226

Nme1-Traf4

0.702558

227

Cdh2-Epha4

0.702558

228

App-Rgs17

0.706795

229

Park7-Traf4

0.708945

230

Hnrnpk-Sdcbp

0.708945

231

Gaa-Traf4

0.715371

232

Cdh2-Iqgap1

0.718873

233

Crk-Rgs17

0.720778

234

App-Rab18

0.720778

235

Hnrnpk-Rab18

0.734704

236

Mtpn-Pdpk1

0.741461

237

App-Itpr1

0.741461

238

Crk-Pdpk1

0.748081

239

Arcn1-Rab5a

0.748573

240

Crk-Rab18

0.748573

241

App-Tulp3

0.748573

242

Mapre1-Pdpk1

0.75474

243

Crk-Iqgap1

0.75474

244

App-Pdpk1

0.761439

245

Cst3-Pdpk1

0.768177

246

App-Furin

0.770339

247

B2m-Rab29

0.789841

248

App-Adcy9

0.789841

249

Crk-Rab29

0.795528

250

App-Chrna4

0.803483

251

B2m-Gabre

0.807737

252

Hnrnpk-Magi3

0.807737

253

B2m-Fgfr1

0.809444

254

B2m-Cd14

0.809444

255

Crk-Rgs14

0.815277

256

Cdh2-Fgfr1

0.816462

257

B2m-Ager

0.81707

258

App-Adcy2

0.81707

259

Cfl1-Fgfr1

0.823521

260

App-Ager

0.830601

261

App-Slc9a3r1

0.830601

262

Cst3-Fgfr1

0.83062

263

Ccn2-Fgfr1

0.83776

264

App-Gabrb3

0.857494

265

App-Rhoc

0.860922

266

App-Adap2

0.866729

267

Cdh2-Prkca

0.868594

268

B2m-Rhoc

0.868594

269

B2m-Gabrb3

0.870856

270

App-Kitl

0.870856

271

Cfl1-Rala

0.883994

272

Crk-Sipa1l1

0.888889

273

Crk-Rala

0.89172

274

Hnrnpk-Rala

0.896359

275

Hmox1-Rala

0.899463

276

App-Rab3b

0.899463

277

Mapre1-Rala

0.90387

278

App-Cav1

0.907223

279

App-Dner

0.910611

280

Crk-Rab9

0.922795

281

B2m-Gp6

0.923752

282

Crk-Traf4

0.926655

283

Nme1-Inpp5d

0.930605

284

App-Tnfrsf19

0.936838

285

Crk-Ralgps2

0.942057

286

B2m-Ptk2b

0.949821

287

B2m-Tnfrsf19

0.949868

288

App-Ptk2b

0.957627

289

B2m-Gabra3

0.957627

290

App-Pdgfra

0.962844

291

Ccl3-Ptk2b

0.965477

292

App-Epha4

0.965477

293

Cfl1-Ptk2b

0.973369

294

B2m-Gabrr2

0.981304

295

App-Tnfsf13b

0.997303

296

Crk-Ifnar2

0.997303

297

B2m-Nfam1

1

298

Ccn2-Ror2

1

299

Igfbp5-Itgb3

1

300

Cfl1-Rab35

1

301

Lgals1-Rac1

1

302

B2m-Sla2

1

303

Mapre1-Ube2b

1

304

Igf1-Sla2

1

305

Nme1-Rac1

1

306

B2m-Il6ra

1

307

Hmox1-Il6ra

1

308

Cst3-Grin2c

1

309

Igf1-P2ry6

1

310

Prdx6-Rhoa

1

311

Prdx6b-Rhoa

1

312

Ccn2-Il6ra

1

313

Lgals1-Rab10

1

314

Pdia3-Rab5a

1

315

Crk-Rab5a

1

316

Igf1-Skap1

1

317

Igf1-Avpr1a

1

318

Cdh2-Itgb3

1

319

Cfl1-Rhoa

1

320

Cfl1-Rock2

1

321

Crk-Rhoa

1

322

Crk-Rock2

1

323

Cnbp-Rab5a

1

324

Park7-Rac1

1

325

Crk-Rab35

1

326

Arcn1-Rab10

1

327

Crk-Rab10

1

328

App-Gnaz

1

329

Mapre1-Rac1

1

330

Cfl1-Gpr65

1

331

B2m-Fgd2

1

332

Hmox1-Sla2

1

333

Crk-Arhgap33

1

334

Nme2-Tgfbr1

1

335

Park7-Rhoa

1

336

Cdh2-Ptprt

1

337

Crk-Rac1

1

338

Pdia3-Rab11a

1

339

Crk-Rit1

1

340

Igf1-Itgb3

1

341

Cdh2-Dlg4

1

342

Igf1-Inpp5d

1

343

Crk-Skap1

1

344

Cdh2-Grin2b

1

345

Igf1-Rhoa

1

346

App-Rab10

1

347

Igf1-Rac1

1

348

Mapre1-Rab11a

1

349

Igf1-Prkca

1

350

B2m-Skap1

1

351

Hmox1-Inpp5d

1

352

Crk-Inpp5d

1

353

Prdx5-Ube2b

1

354

Sec22b-Ube2b

1

355

Cnbp-Rab11a

1

356

B2m-Adgra3

1

357

B2m-Ube2b

1

358

Cst3-Rac1

1

359

Arcn1-Rac1

1

360

Cfl1-Rab14

1

361

App-Skap1

1

362

Hnrnpk-Rhoa

1

363

B2m-Gab2

1

364

Prdx6-Rac1

1

365

Prdx6b-Rac1

1

366

Nme2-Inpp5d

1

367

App-Rab14

1

368

B2m-Ly6e

1

369

App-Rab35

1

370

Mapre1-Tgfbr1

1

371

Arcn1-Rhoa

1

372

Cfl1-Rac1

1

373

Cst3-Rhoa

1

374

Gfap-Prkca

1

375

Crk-Sla2

1

376

B2m-Spn

1

377

App-Rasl10b

1

378

Ccn2-Tgfbr1

1

379

Lgals3-Tgfbr1

1

380

Ltbp2-Tgfbr1

1

381

Crk-Rgs19

1

382

B2m-Adgra2

1

383

Cdh2-Rab5a

1

384

Hnrnpk-Rab5a

1

385

Hnrnpk-Rab14

1

386

Ccn2-Prkca

1

387

Arcn1-Tgfbr1

1

388

Crk-Rasl10b

1

389

Crk-Plek2

1

390

Cnbp-Ube2b

1

391

Sod1-Tgfbr1

1

392

App-Prkca

1

393

Crk-Usp8

1

394

Lgals1-Rhoa

1

395

Hnrnpk-Rab11a

1

396

App-Lancl2

1

397

B2m-Rab9

1

398

Cst3-Tgfbr1

1

399

Sod2-Tgfbr1

1

400

Mtpn-Rhoa

1

401

B2m-Rit1

1

402

Crk-Fgd2

1

403

Igf1-Tgfbr1

1

404

Cst3-Prkca

1

405

B2m-Rasgrf2

1

406

Crk-Rasgrf2

1

407

Crk-Gpr65

1

408

Cdh2-Inpp5d

1

409

App-Grin2b

1

410

Hnrnpk-Tgfbr1

1

411

Crk-Ube2b

1

412

Igfbp2-Prkca

1

413

Crk-L1cam

1

414

App-Drd1

1

415

Igfbp5-Tgfbr1

1

416

B2m-Gabrr1

1

417

Crk-Tgfbr1

1

418

Cfl1-Inpp5d

1

419

Cdh2-Rhoa

1

420

Igfbp2-Tgfbr1

1

421

Crk-Rrad

1

422

Crk-Grin2b

1

423

Mtpn-Tgfbr1

1

424

Crk-Rgs9

1

425

App-Rab11a

1

426

App-Arap3

1

427

Crk-Lancl2

1

428

Arcn1-Prkca

1

429

App-Sipa1l1

1

430

B2m-C3ar1

1

431

Crk-Rasd2

1

432

App-Gabra3

1

433

Sec22b-Tgfbr1

1

434

B2m-Celsr2

1

435

Crk-Il6ra

1

436

Crk-Lpar1

1

437

App-Chrnb1

1

438

App-Fgfr1

1

439

App-Rhoa

1

440

App-Grik2

1

441

App-L1cam

1

442

Crk-Prkca

1

443

B2m-Rab10

1

444

Pea15a-Tgfbr1

1

445

Crk-Rab9b

1

446

App-Celsr2

1

447

Crk-Atp6ap2

1

448

Lgals1-Tgfbr1

1

449

App-Rasgrf2

1

450

App-Ghr

1

451

Crk-Gna11

1

452

Crk-Rgs6

1

453

Lxn-Tgfbr1

1

454

App-Grik4

1

455

App-Tgfbr1

1

456

App-Unc5b

1

457

App-Hrh3

1

458

Crk-Magi3

1

459

App-Fgd2

1

460

Crk-Ptprc

1

461

App-Bmpr2

1

462

App-Avpr1a

1

463

App-Rab5a

1

464

App-Unc5a

1

465

App-Arhgap10

1

466

B2m-Rab5a

1

467

Cfl1-Tgfbr1

1

468

App-Bdkrb2

1

469

B2m-Rac1

1

470

B2m-Tgfbr1

1

471

B2m-Prkca

1

472

App-Traf4

1

473

App-C3ar1

1

474

App-Fzd5

1

475

App-Ptprc

1

476

App-Sdcbp

1

477

App-Mib1

1

478

App-Lpar1

1

479

App-Rala

1

480

App-Rgs6

1

481

App-Mras

1

482

App-Trpv4

1

483

App-Elmo1

1

484

App-Gabrr2

1

485

App-Chrng

1

486

App-Rock2

1

487

App-Inpp5d

1

488

App-Pdgfrb

1

489

App-Nmur1

1

490

App-Usp8

1

491

App-Sla2

1

492

App-Rasd2

1

493

App-Jag2

1

494

App-Rgs19

1

495

App-Rgs20

1

496

App-Dok3

1

497

App-Adcy4

1

498

App-Ly6e

1

499

App-Acvrl1

1

500

App-Ptprt

1

501

App-Il6ra

1

502

App-Npffr2

1

503

App-P2ry4

1

504

App-Itk

1

505

App-Gna11

1

506

App-Ddr1

1

507

App-Chrna6

1

508

App-Adcy3

1

509

App-Epha1

1

510

App-Plxna1

1

511

App-Ube2b

1

512

App-Csf1r

1

513

App-Magi3

1

514

App-Sri

1

515

App-Cd79b

1

516

App-Itgam

1

517

App-Ror2

1

518

App-Unc13a

1

519

App-Cd274

1

520

App-Lpar6

1

521

App-Olfr187

1

522

App-C5ar2

1

523

App-Rgs9

1

524

App-Grin2c

1

525

App-Tnfsf12

1

526

App-Iqgap1

1

527

App-Grm1

1

528

App-Cd3e

1

529

App-Olfr1444

1

530

App-Rit1

1

531

App-Rac1

1

532

App-Gabre

1

533

App-Rab9

1

534

App-Oprl1

1

535

App-Olfr1052

1

536

App-Arhgap33

1

537

App-Rras2

1