Fig. 2: Examples for robust capsids in the liver, lung, brain, and musculature. | Nature Communications

Fig. 2: Examples for robust capsids in the liver, lung, brain, and musculature.

From: Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants

Fig. 2

a Top 10 AAV variants in the second library and the shown tissues based on normalized transcriptional efficiency (Vαβ). Depicted values are the average from six C57BL/6 J mice with SD. b Transcriptional specificity (Tαβ) of the shown four capsids as normalized proportion per cell (diploid genome, dg) in abdominal aorta (Aa), thoracic aorta (At), brain (B), blood cells (BlC), colon (C), diaphragm (Di), duodenum (Du), eye, brown fat (FatB), white fat (FatW), heart (H), inner ear (I), kidney (K), liver (Li), lung (Lu), ovaries (O), pancreas (P), quadriceps femoris (QF), spleen (S), and stomach (St). Depicted are average cDNA values from six C57BL/6 J mice with SD. Colors in a and b highlight the same capsids in both panels. Source data are available in the Source data file.

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