Fig. 3: Substrate scope of the Mannich reactiona. | Nature Communications

Fig. 3: Substrate scope of the Mannich reactiona.

From: Diastereodivergent chiral aldehyde catalysis for asymmetric 1,6-conjugated addition and Mannich reactions

Fig. 3

aReaction conditions: 6 (0.1 mmol), 7 (0.13 mmol), ent-3b or 4f (0.01 mmol), DBU (0.07 or 0.03 mmol), CH2Cl2 (0.5 mL) or o-xylene (1.0 mL), at 0 oC or −10 oC. bIsolated yield. cDetermined by 1H NMR. dEe of the major diastereoisomer determined by chiral HPLC. eUsing toluene as solvent. fUsing 3d as a catalyst. gAt 0 oC.

Back to article page