Fig. 1: Overall structure of human SRD5A2.
From: Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
a 5α-reduction reaction of the ∆4,5 double bond of testosterone catalyzed by SRD5A2 to generate dihydrotestosterone (DHT). b SRD5A2 inhibition by finasteride and dutasteride. The two inhibitors share the same ring structure with different R-groups connected to the amide side chains. c–e Three views of the SRD5A2 structure. The NADP–DHF adduct was shown as spheres. L1–6 represent six loops connecting 7-TMs. The NADP and DHF moieties were colored in light cyan and light pink, respectively.
