Fig. 2: EOS-deficiency exacerbates cardiac dysfunction post-MI.
From: Eosinophils improve cardiac function after myocardial infarction
a Mouse surgery strategy. b Representative LV M-mode echocardiography images from WT and ∆dblGATA mice at 1-month post-MI or sham. c Cardiac functions at 1-month post-MI: EF, FS, LV Vol;d, LV Vol;s, HW/BW ratio, HW/TL ratio, and mortality rate in different groups of mice as indicated. d Infarct size ratio, infarct thickness, and calculating formulas. e H&E staining for d Scale: 1500 µm. f TUNEL-positive apoptotic cells in infarct region. Scale: 100 µm, inset: 40 µm. g Masson’s trichrome staining determined collagen deposition in the infarct region. Scale: 1500 µm. Representative images in f and g are shown to the right. h, i. Immunoblots detected IL4 (h) and mEar1 (i) expression in heart from WT and ∆dblGATA sham and MI mice at 1-day and 1-month post-MI. Data are mean ± SEM. The numbers mice of in each experimental group and P values are indicated (c, d, f–i), one-way ANOVA test (c, h, i) and non-parametric Mann-Whitney U test (d, f, g).
